Paxlovid Information for the Public


Paxlovid is given to treat mild-to-moderate COVID-19 in patients 12 years of age and older who are at high risk for progression to severe COVID-19, including hospitalization or death, and who meet the current Priority Eligibility Criteria.

Paxlovid Fact Sheet for Patients, Parents and Caregivers

Frequently Asked Questions About Paxlovid

On December 22, 2021, the U.S. Food and Drug Administration (FDA) issued an Emergency Use Authorization (EUA) for the medication PAXLOVID. PAXLOVID is an oral antiviral medication used for treating mild-to-moderate COVID-19 in adults and pediatric patients 12 years of age and older weighing at least 40 kg (88 lbs) and who are at high risk for severe COVID-19, including hospitalization or death.

A healthcare provider will determine whether PAXLOVID is an appropriate treatment for COVID-19.

How does PAXLOVID work?

PAXLOVID keeps the virus that causes COVID-19 from reproducing, preventing you from getting sick.

How do I know if I am a candidate for PAXLOVID?

  • Your healthcare provider will determine if you are a candidate for PAXLOVID. At a minimum you must have mild-to-moderate COVID-19, be over 12 years of age and weigh at least 40 kg (88 lbs), and who are at high risk for severe COVID-19, including hospitalization or death, meeting certain high-risk eligibility criteria established by MDHHS. These currently include one of the following:
    • You have a condition or take a medication that causes moderate to severe immunocompromise regardless of your vaccine status
    • Are 75 years or older regardless of vaccination status
    • Ages 65-74 years and not up to date or with MI Priority Risk Factors
    • Pregnant and not up to date
    • Ages 12 years and older not up to date and with MI Priority Risk Factors

MI priority risk factors include:

  • Obesity (BMI > 35)
  • Chronic respiratory disease (e.g., COPD, moderate or severe asthma requires daily inhaled corticosteroid, bronchiectasis, CF, ILD)
  • Pregnancy (Note: In pregnancy, molnupiravir should not be used and Paxlovid and remdesivir should be used with caution when sotrovimab is unavailable)
  • Chronic Kidney Disease (stage III, IV, or end stage CKD-GFR) (special considerations with Paxlovid)


Is there anything I need to tell my healthcare provider before PAXLOVID is prescribed?

Please let your health care provider know if any of the following apply:

  • Allergies.
  • Liver or kidney disease.
  • If you are pregnant or plan to become pregnant.
  • Are breastfeeding.
  • Have any serious illness or medical history.
  • If you are taking oral contraceptives.
  • Provide your provider with a list of all your current medications.

How is PAXLOVID given?

  • The medication must be started within 5 days of symptom onset.
  • A qualified health care provider must prescribe PAXLOVID
  • Dosing of PAXLOVID is nirmatrelvir tablets co-packaged with ritonavir tablets
    • 300 mg nirmatrelvir (two 150 mg tablets) oval, pink immediate-release, film-coated tablets with "PFE" on one side and "3CL" on the other side
    • with 100 mg ritonavir (one 100 mg tablet), white film-coated ovaloid tablets with the "a" logo and the code "NK"
    • all three tablets taken together by mouth and swallowed twice daily for 5 days
  • Some patients with certain forms of kidney disease may need to take PAXLOVID differently than described above. This will be explained by the pharmacist and written on the label.
  • Ask the dispensing pharmacist if you have any questions about how to take PAXLOVID.
  • If you feel worse, or do not feel better after 5 days, contact your healthcare provider.
  • Side effects may include liver problems, resistance to HIV medications, altered sense of taste, diarrhea, hypertension (high blood pressure), and muscle aches.


How much will PAXLOVID cost me?

Currently, PAXLOVID is provided by the federal government at no charge to you. Pharmacies dispensing PAXLOVID may bill insurance providers for the cost of dispensing the medication. Patients should not experience out-of-pocket costs.

Where can I fill my PAXLOVID prescription?

PAXLOVID is available at select pharmacies across the state including 47 Michigan Meijer locations.

I meet the FDA eligibility criteria, but my health care provider tells me I am still not eligible to receive this medication. Why?

Because supply of PAXLOVID is limited, MDHHS put in place additional eligibility criteria that prioritizes the medication to those who are at higher risk for hospitalization or death from COVID19. These are based on recommendations from the National Institutes of Health. As the supply improves, eventually, we expect to be able to make PAXLOVID available to all who meet the FDA indications for use.